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Why must both routes to a positive result be included in the denominator of Bayes' theorem?

The denominator P(B)P(B) in Bayes' theorem represents the total probability of the evidence (event B). In the context of a screening test, a positive result can arise from two mutually exclusive scenarios: a true positive (person has the disease and tests positive) or a false positive (person does not have the disease but tests positive). To correctly normalize the posterior probability, the denominator must account for all possible ways the evidence can occur. Ignoring the false positive route would underestimate the total probability of a positive test, leading to an inflated and incorrect posterior probability of disease.

Conditions

  • The evidence event B can occur via multiple mutually exclusive paths.
  • The law of total probability applies.

Reasoning, step by step

  1. Identify all mutually exclusive scenarios that lead to the evidence event B.
  2. Calculate the probability of each scenario (joint probability).
  3. Sum these probabilities to find the total probability of B.
  4. Use this sum as the denominator in Bayes' theorem.
  5. Verify that this normalization ensures the posterior probabilities sum to 1.

Example

The script states: 'Include both routes to a positive result... the positive probability is 0.12(0.95)+0.88(0.06)=0.16680.12(0.95)+0.88(0.06)=0.1668. Dividing the true-positive probability by this total gives about 68.3%.'

Common misconceptions

  • Thinking that only the true positive path contributes to the probability of a positive test.
  • Believing that the denominator is simply the prior probability of the hypothesis.
  • Confusing the marginal likelihood with the joint likelihood.

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